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Big Bang Nucleosynthesis
Light elements (namely deuterium, helium, and lithium) were produced in the first few minutes of the Big Bang
Elements heavier than 4He are produced in the stars and through supernovae
However, enough helium and deuterium cannot be produced in stars to match what is observed because stars destroy deuterium in their cores
So all the deuterium we see must have been made around three minutes after the big bang, when T~109 K
BBN predicts that 25% of the matter in the Universe should be helium, and about 0.001% should be deterium, which is what we see